Illustrated Guide to Percutaneous Collagen Induction, Fernandes D, Aust M, Bahte, S

Microneedling therapy, also referred to as collagen induction therapy (CIT), and percutaneous collagen induction (PCI), is a minimally invasive skin-rejuvenation procedure that in Onsen Skin Health involves the use of a device called a Dermapen.

The disposable cartridge contains needles that are used to puncture the skin to create a controlled microscopic wound.

These micro-injuries trigger a healing response from the body to produce new collagen and elastin.

Each puncture creates a channel that triggers the body to fill these microscopic wounds by producing new collagen and elastin.

Collagen and elastin are the main fibres that form the extracellular matrix. Both are formed by fibroblasts.

Collagen is responsible for tensile strength and elastin provides elasticity to the skin. Production and density of both decreases as a function of age, and results in sagging and wrinkling.

Wounding alters the amount and quality of these fibres. Thus, neocollagenesis and neoelastinogenesis hold the key to managing aesthetic conditions such as ageing and scarring.

Because the epidermis remains intact throughout treatment, the procedure can be repeated safely and is also suited to regions where laser treatments and deep peels are not typically performed, e.g. the eye area. There is also no risk of dyspigmentation associated with ablative procedures.




Histologic examinations have confirmed a considerable increase in collagen and elastin deposition at 6 months postoperatively.

The epidermis demonstrated 40 percent thickening of stratum spinosum and normal rete ridges at 1 year postoperatively.

(Percutaneous Collagen Induction Therapy: an alternative treatment for scars, wrinkles, and skin laxity. Aust MC, Fernandes D, Kolokythas, P, Kaplan HM, Vogt PM)